KLB ELISA Kit for Human(Homo sapiens) | EIAab.comKLB ELISA Kit for Human(Homo sapiens)

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Index > Protein center > KLB(Gene name) > Human

KLB (Gene name),

Beta-klotho (Protein name ), KLOTB_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

KLB;

Protein name:

Beta-klotho(BKL;BetaKlotho);

Alternative:

Klotho beta-like protein;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with FGFR1 and FGFR4 (By similarity). Interacts with FGF19; this interaction is direct. Interacts (via C-terminus) with FGF21; this interaction is direct.

Function:

Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21.

Subcellular Location:

Cell membrane Single-pass type III membrane protein

Protein Attributes:

Sequence length:

1044

Sequence:

50:

100:

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1044:

GCCFFSTLVL | LLSIAIFQRQ | KRRKFWKAKN | LQHIPLKKGK | RVVS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:152831

String:

Q86Z14

UniGene:

Hs.90756

Pfam:

PF00232

STRING:

9606.ENSP00000257408

SMR:

Q86Z14

MIM:

611135

Uniprot:

Q86Z14

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ELISA Kit for Human BKL

Cat.:

E1003h

Price:

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Human BKL

Cat.:

E1003m

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human BKL

Cat.:

U1003h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human BKL

Cat.:

U1003m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human BKL

Cat.:

P1003Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human BKL

Cat.:

P1003Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human BKL

Protein for Human BKL

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Klotho beta like protein."
Hayashi A. , Saito T.
Submitted (2002-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Liver.
3.

"C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors."
Wu X. , Lemon B. , Li X. , Gupte J. , Weiszmann J. , Stevens J. , Hawkins N. , Shen W. , Lindberg R. , Chen J.-L. , Tian H. , Li Y.
J. Biol. Chem.283:33304-33309(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FGF19 AND FGF21
4.

"Different roles of N- and C- termini in the functional activity of FGF21."
Micanovic R. , Raches D.W. , Dunbar J.D. , Driver D.A. , Bina H.A. , Dickinson C.D. , Kharitonenkov A.
J. Cell. Physiol.219:227-234(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FGF21

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